The three players to drop out from Saturday's starting XI are Gael Clichy, Leroy Sane and Kelechi Iheanacho.
There's no Iheanacho or Vincent Kompany on the bench as the Blues look to avoid defeat against the La Liga giants for the first time in a competitive fixture.
Will Kevin De Bruyne, Raheem Sterling or Nolito take the mantle as City's lone striker - or will all three interchange throughout the evening? It looks as though Fernandinho and Ilkay Gundogan will sit deeper with David Silva more advanced.
Kolarov and Zabaleta will be tasked with John Stones and Nicolas Otamendi to stop Barca's marauding front line...
For the hosts, Sergi Roberto returns and Jordi Alba also returns to leave the Catalans pretty much at full strength.