Manchester City will be without Bacary Sagna for the trip to Southampton, but skipper Vincent Kompany is pushing for a starting spot.
Sagna is making good progress after an adductor injury but is not ready yet, while Kompany is fully fit again after suffering a small reaction following his impressive 90 minutes against Chelsea last Wednesday.
Guardiola said of his Belgian centre-back: "After the game against Chelsea he had a little problem in his legs, and we didn’t want to take the risk, but of course the good news is he was able to play 90 minutes in a tough game at Stamford Bridge at a high level."
Guardiola is expecting a tough game against Southampton, who left an impression on the boss when they drew 1-1 draw earlier this season.
"Southampton are having an exceptional season," Guardiola said. "They have a good manager and players in all positions. They have very good midfielders, the strikers are so fast, the wingers can play inside, all of them good quality. I was really impresed when they came here in what was a busy time for us. It will be a really good test."
Claude Puel's side have won their last two games, against Crystal Palace (h) and West Brom (a) and sit ninth in the Premier League.